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Three‐day fasting limits reperfusion ventricular arrhythmias
Author(s) -
Snorek Michal,
Hodyc Daniel,
Neckar Jan,
Tousek Frantisek,
Wilhelm Jiri,
Kolar Frantisek,
Herget Jan
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.50
Subject(s) - medicine , cardiology , ischemia , ventricular tachycardia , occlusion , ventricular fibrillation , anesthesia , endocrinology
In ischemic tissues, the oxidation of NADH to NAD+ is impaired. This constitutes the conditions of the reductive stress. Then, higher rates of reactive oxygen species production can be observed. Fasting before exposure to ischemia should increase ketogenesis, which consumes NADH and thus eliminates the reductive stress. We investigated whether the three‐day fasting affects the incidence and severity of ventricular arrhythmias occurring during myocardial ischemia and reperfusion in adult male Wistar rats. Anesthetized open‐chest animals were subjected to 20‐min left anterior descending coronary artery occlusion followed by reperfusion. A single‐lead electrocardiogram was recorded and arrhythmias were assessed according to the Lambeth Conventions. Fasting did not affect ischemic arrhythmias: neither the number of premature ventricular complexes (PVCs) nor the total duration of ventricular tachycardia (VT) differed between fasting and control groups. The number of PVCs during early reperfusion phase was significantly (p<0.005) reduced in fasting rats (5 ± 2) compared to controls (186 ± 41). VT was absent in fasting animals while controls exhibited total VT duration of 18 ± 4 s. We suppose that fasting decreases reductive stress in reperfusion. Subsequent reduction of the free radical damage could provide its antiarrhythmic effect. Supported by Grant GACR 305/08/0108 and MSMT 1M 0510