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Dynamics of acute and memory mucosal and systemic immune responses against HIV‐1 envelope following immunizations through single or combinations of mucosal and systemic routes
Author(s) -
Vajdy Michael,
Srivastava Indresh,
Zhou Fengmin,
Sun Yi,
Barnett Susan,
Goodsell Amanda
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.487
Subject(s) - immune system , immunization , medicine , immunology , immunity , mucosal immunity , mucous membrane of nose , nasal administration , antibody
In this study, immunizations at 2 vs. 6 weeks intervals, with an HIV‐1 envelope protein in adjuvants, through intra‐nasal (IN), intra‐muscular (IM), IN followed by IM (IN/IM) and IM/IN, were compared for induction of mucosal and systemic immune responses. IN/IM immunizations at 2, but not at 6, week intervals induced the highest mucosal and systemic immune responses compared to other immunization routes. Following a resting memory phase, IN boosting of IN/IM‐immunized mice, compared to IM‐boosting of IM‐immunized mice, induced increased IgA responses. Thus, depending on the immunization intervals, IN/IM may be more effective than IM immunizations for short‐ and long‐term immunity.