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Differential suppression of allergen‐induced airway inflammation in murine model of asthma by lactic acid bacteria
Author(s) -
Hong Hye Jin,
Kim Eugene,
Kim Tae Sung
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.481
Subject(s) - lactobacillus sakei , lactobacillus plantarum , lactobacillus , immunology , inflammation , immunoglobulin e , probiotic , lactococcus lactis , allergen , medicine , in vivo , lactic acid , microbiology and biotechnology , bacteria , biology , allergy , antibody , genetics
Probiotics are demonstrated to be effective in reducing allergic symptoms. However, there are few reports to investigate therapeutic effects of lactobacillus on allergen‐induced airway inflammation. In this study, we examined whether lactic acid bacteria had therapeutic effects on lung airway inflammation. Three different strains of lactobacillus isolated from Korean traditional food Kimchi ( L. plantarum , L. sakei subsp. sakei and L. curvatus ) were chosen and evaluated in murine asthma model using ovalumin (OVA) as a model allergen. Airway hyperresponsiveness was suppressed in all lactobacillus‐administered mice, with the highest inhibition in the L. plantarum ‐administered group. The mRNA expression levels of genes related to mucus production were down‐regulated in lung homogenates of the lactobacillus‐administered mice. In addition, the levels of IL‐4 production in lymph node cells and IgE in sera were significantly lower in the lactobacillus‐administered mice than in untreated mice. Importantly, production levels of IL‐4 and IL‐13 were lower in bone marrow‐derived dendritic cells than those administered with other two strains, whereas the expression of IFN‐γ and IL‐12 were similarly up‐regulated in all lactobacillus‐treated groups. These results indicate that lactic acid bacteria may differentially suppress allergen‐induced airway inflammation through up‐regulation of Th1 cytokines and downregulation of Th2 cytokines in dendritic cells in vivo , and suggest that L. plantarum isolated from Kimchi is an effective probiotic for inhibiting allergic airway diseases.