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Intermittent fasting: fly in the oatmeal
Author(s) -
Talan Mark I,
Ahmet Ismayil,
Wan Ruiqian,
Mattson Mark P,
Lakatta Edward G
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.44
Subject(s) - preload , medicine , cardiology , inotrope , diastole , cardiac function curve , stroke volume , ejection fraction , end diastolic volume , cardiac output , blood pressure , anesthesia , hemodynamics , heart failure
Intermittent fasting (IF), a dietary regimen of periodical fast (for example, every other day), results in weight loss and may have multiple health benefits. In rodents IF increases the life span and reduces the incidence of age‐associated diseases. We have reported strong neuroprotective and cardioprotective effects of IF against ischemic injury. The objective of this study was to assess the effect of long term IF on cardiac structure and function. Two groups of 4 mo old male SD rats were subjected to either IF or a regular diet for 3 months and then cardiac function was evaluated by echocardiogtrapy followed be pressure‐volume (P‐V) loop analyses under normal conditions and under stress induced by inotropic stimulation and volume load. Echocardiography showed a relative LV enlargement with a small reduction of ejection fraction and substantial increase of left atrial size in IF rats. P‐V loop analyses revealed indices of diastolic dysfunction. During the stress test the Preload Recruitable Stroke Work and the ratio of End‐diastolic volume to End‐diastolic pressure were lower in IF than in control rats, unmasking a diminishing cardiac reserve and reduced diastolic capacity in IF . The present data suggest that effects of IF on the cardiovascular system are not entirely beneficial. The work was supported by Intramural Research Program of NIA.