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The Role of Foxo1 In The Development and Function Of B Cells
Author(s) -
Chang ShihEn,
Zheng Biao Q
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.404
Subject(s) - foxo1 , transcription factor , microbiology and biotechnology , conditional gene knockout , biology , protein kinase b , b cell , cell growth , breakpoint cluster region , cd19 , cell , signal transduction , receptor , phenotype , immunology , gene , genetics , antibody
Foxo transcription factors regulate several cellular processes, including apoptosis, cell‐cycle progression, metabolism and oxidative stress response. Foxo belongs to the forkhead box transcription‐factor family and is a downstream target of AKT protein kinase. After being phosphorylated and inhibited by AKT, Foxo is exported to the cytoplasm from the nucleus and becomes inactive. Studies have shown that Foxo1 affects B‐cell proliferation and class switching recombination, and is down‐regulated in B cells following B‐cell antigen receptor (BCR) signaling. However, whether Foxo1 is required for the proper development and function of the B‐cell lineage remains to be learned. In order to study the role of Foxo1 in the development and function of B cells, Foxo1 conditional knockout (CKO) mice in the B‐cell lineage were generated by crossing CD19‐cre with Foxo1 f/f mice. Foxo1 B‐cell CKO mice show abnormality in B‐cell development and maturation. A decrease population of mature B cells in these mice was observed compared to wild type mice. In addition, Foxo1 −/− B cells exhibit defective proliferation in response to stimulation through BCR. The detailed mechanisms of how Foxo1 regulates the development and function of B cells will be further elucidated.