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Herpesvirus assembly and disassembly triggers recruitment of the dynein motor by a viral structural protein
Author(s) -
Smith Greg Allan,
Zaichick Sofia
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.259
Subject(s) - capsid , dynein , herpes simplex virus , virology , microtubule , biology , varicella zoster virus , virus , herpesviridae , subfamily , structural protein , encephalitis , microbiology and biotechnology , viral disease , genetics , gene
The neuroinvasive herpesviruses are a highly‐prevalent group of the alpha‐herpesvirus subfamily that includes the human pathogens: herpes simplex virus types 1 and 2 (HSV–1, HSV‐2), and varicella zoster virus (VZV). Several severe forms of disease (i.e. herpes keratitis, encephalitis, shingles) arise from the transport of these viruses in nerves of the peripheral or central nervous system, a process which is dependent upon the microtubule motor dynein. We demonstrate that a viral structural protein, VP1/2, is initially expressed in an inactive form, but when bound to the herpesvirus capsid becomes competent and is sufficient to mediate microtubule‐dependent transport in cells.