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Vagotomy diminished airway constriction provoked by different doses of Eserine
Author(s) -
Jakupaj Muharrem,
Neziri Burim,
Krasniqi Avdyl,
Devaja Shqipe
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.168
Subject(s) - bronchoconstriction , vagotomy , anesthesia , airway resistance , medicine , vagus nerve , pulmonary compliance , airway , lung , stimulation
Although of extensive study, yet the central mechanisms involved in airway hyperractivity and bronchoconstriction remain poorly understood. In our study realized in ferrets we observed that blockade of cholinesterase activity by systemic administration of increased doses of eserine evokes airway bronchoconstriction. Experiments were performed on 6 male European ferrets, Mustella putorius furo (700–900 gr), anesthetized, paralyzed and artificially ventilated. Parameters of lung mechanics such as lung resistance (RL), dynamic compliance (Cdyn) and pressure in bypassed tracheal segment (Ptseg) will be measure before and after asphyxia test induced by the interruption of ventilation for 30–45 seconds. After the control measurements are obtained, eserine has been administered systematically, starting from dose 10 μg/kg body weight, after 15 minutes additional 30 μg/kg body weight, and after another 15 minutes, additional 60 μg/kg body weight. After each dose administration, lung resistance (RL), dynamic compliance (Cdyn) and pressure in bypassed tracheal segment (Ptseg) have been measured. Next challenge with asphyxia has been repeated after bilateral vagal nerve cutting (vagotomy). After bilateral vagotomy, administration of eserine with the same doses as before vagotomy, has been given and measurements of lung resistance (RL), dynamic compliance (Cdyn) and pressure in bypassed tracheal segment (Ptseg) has been repeat. These studies indicate that vagal nerves have a crucial role, in transmission of impulses comes from central nervous system, in regulating the respiration process by contraction or relaxation of airway smooth muscle tone.