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Exercise training and renal denervation attenuate the expression of angiotensin II Type 1 and 2 receptors in rabbits with chronic heart failure
Author(s) -
Clayton Sarah C,
Curry Pamela L,
Li Yu,
Zucker Irving H
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.159
Subject(s) - denervation , angiotensin ii receptor type 1 , medicine , endocrinology , angiotensin ii , receptor , kidney , renin–angiotensin system , renal cortex , angiotensin receptor , heart failure , chemistry , blood pressure
In order to study the role that vascular Angiotensin II (Ang II) receptors play in the kidney in heart failure (HF), rabbits were subjected to 3 weeks of rapid ventricular pacing. The cortex was sieved to obtain a vessel enriched sample and probed for expression of Ang II receptors. In HF, the expression of the Ang II type 1 receptor (AT 1 R) was significantly increased and Ang II type 2 receptor (AT 2 R) was decreased compared to sham rabbits. Because exercise training (ExT) has been shown to have an effect on Ang II in HF we examined cortical Ang II receptor expression. While there was no change in the expression of either protein in the sham rabbits subjected to ExT, the HF rabbits that were ExT showed a reversal of the expression pattern. Another group of animals were subjected to unilateral renal denervation. Denervation also showed a near normalization of the expression pattern; AT 1 R was decreased and AT 2 R was increased (see table). These data suggest that increases in the ratio of AT 1 to AT 2 R expression in the renal cortex may contribute to the cardio‐renal syndrome in HF. ExT and renal denervation may have similar final pathways that provide benefit in HF.