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Effect of training intensity on subcutaneous adipose LPL, HSL, and PPAR‐ƒ× mRNA expression in middle‐aged women
Author(s) -
Han Taekyung,
Park Soohyun,
Kim Donghyun,
Kim Taewoon,
Woo Sanggu,
Ann Euisoo
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.119
Subject(s) - adipose tissue , lipoprotein lipase , medicine , endocrinology , abdominal fat , obesity
Objective: Exercise training has been used as an effective and non‐pharmacologic means for abdominal obesity because it selectively reduces abdominal fat mass while preserving lean body mass. However, the ideal training intensity necessary to maximize abdominal fat loss is unknown. The goal of this study was to determine the cellular mechanisms by which training intensity affects the loss of abdominal adipose tissue. Methods: A total of 30 women participated in either a moderate (N=15, aged 41.1±6.0 yrs, 50% VO 2 max) or vigorous (N=15, aged 46.5±5.6 yrs, 80% VO2max) walking program lasting for 12 weeks (3 days/week, 400 kcal/session). Abdominal subcutaneous adipose biopsies were taken for the assessment of lipoprotein lipase (LPL), hormone‐sensitive lipase (HSL), and peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) mRNA expression before and just after the interventions. Post‐heparin releasable LPL contents were measured in circulating plasma. Results: Following the interventions, both groups had significant increases in post‐heparin releasable LPL contents and significant decreases in abdominal adipose LPL, HSL, and PPAR‐γ mRNA levels with no significant group differences. Conclusion: The current findings of the study suggest that exercise volume rather than exercise intensity plays a critical role in losing abdominal adipose tissue including both subcutaneous and visceral ones. This study was supported by the Korean Research Foundation Grant funded by the Korean Government (KRF‐2005‐042‐G00025).