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Effect of training intensity on subcutaneous adipose leptin, adiponectin, interleukin 6, and tumor necrosis factor mRNA expression in middle‐aged women
Author(s) -
Park Soohyun,
Han TaeKyung,
Ann EueSoo,
Yoon EunSun,
Kim Byungroh,
Kang HyunSik
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.118
Subject(s) - adiponectin , adipose tissue , leptin , adipokine , medicine , endocrinology , tumor necrosis factor alpha , obesity , insulin resistance
Objective: Obesity, especially abdominal one, is associated with a whole body pro‐inflammatory state and metabolic syndrome. Adipocytokines secreted by adipose tissue have been suggested as a possible linking between obesity and its related‐metabolic syndrome complications. The goal of this study was to study the effect of training intensity on mRNA levels of leptin, adiponectin, interleukin‐6 (IL‐6), and tumor necrosis factor‐α (TNF‐α) in subcutaneous adipose tissue. Methods: A total of 30 women participated in either a moderate (N=15, aged 41.1±6.0 yrs, 50% VO 2 max) or vigorous (N=15, aged 46.5±5.6 yrs, 80% VO2max) walking program lasting for 12 weeks (3 days/week, 400 kcal/session). Before and just after the walking programs, abdominal adipose biopsies were taken for the assessment of leptin, adiponectin, IL6, and TNF‐α mRNA expression, and their circulating concentrations were also measured in fasting serum. Results: Baseline values in abdominal adipose leptin, adiponectin, and IL‐6 mRNA levels were significantly decreased in both groups following the interventions, with no significant group differences. Baseline values in TNF‐α mRNA levels did not change significantly in both groups. Conclusion: The current findings of the study suggest that regardless of training intensity, aerobic exercise improves pro‐inflammatory state in both circulating plasma and subcutaneous adipose tissue. This study was supported by the Korean Research Foundation Grant funded by the Korean Government (KRF‐2006‐311‐G00022).