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Central and peripheral alytesin cause short‐term anorexigenic effects in neonatal chicks
Author(s) -
Prall Brian Christopher,
Fouse Dawn,
Cline Mark Andrew
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.2_supplement.112
Subject(s) - endocrinology , medicine , hypothalamus , nucleus , peripheral , appetite , lateral hypothalamus , chemistry , biology , neuroscience
We studied the effects of alytesin, an analogue of bombesin, on appetite related responses in chicks. Chicks responded to intracerebroventricular (ICV) and peripheral injections of alytesin with short‐term reduced feed intake. ICV alytesin caused reduced short‐term water intake when feed was present, but this effect was secondary to feed intake since an effect on water intake was not detected in feed‐restricted alytesin‐treated chicks. The anorexigenic effect of both ICV and peripheral alytesin may be mediated at the hypothalamus, since all hypothalamic nuclei studied; regio lateralis hypothalami, nucleus dorsomedialis hypothalami, nucleus paraventricularis magnocellularis, nucleus perventricularis hypothalami, nucleus infundibuli hypothalami and the nucleus ventromedialis hypothalami, were activated as evident by increased c‐Fos immunoreactivity. Central alytesin did not cause increased behaviors that were unrelated to ingestion and did not cause anxiety‐related behavior patterns. Additionally, central alytesin did not affect pecking efficacy. We conclude that both ICV and peripheral alytesin injections induce anorexigenic effects in chicks, and the hypothalamus is involved. While the anorexigenic effects of alytesin and bombesin appear to be conserved across species, the two peptides may differ in other behavioral responses and central mechanisms of action.