Premium
The codes of “non‐coding” RNA: Translating the epigenome of acquired tolerance for recognition of functional self
Author(s) -
Wissler Josef H.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.995.2
Subject(s) - epigenetics , zipper , epigenome , rna , biology , genetics , chemistry , computational biology , gene , dna methylation , gene expression , computer science , algorithm
AIM: Tolerance is a process of tissue indifference or non‐reactivity towards matter normally exciting adverse or immune responses. It concerns all living world in recognition of functional self and discrimination from damaged / junk self and nonself matter with many basic and clinical problems alike. As evident from paradigmatic LeDouarin phenomena and peptidome complexity, intrinsic epigenetic [non‐Mendelian] variation mechanisms are still not understood. Hence, functions of endogenous [oligo‐]RNA / RNP were investigated on tolerance of neovascular patterns [Wissler et al., Protides Biol. Fluids 34 : 517–536, 1986; Materialwiss. Werkstofftech. 32 : 984–1008, 2001; Ann. N. Y. Acad. Sci. 961: 292–297, 2002; 1022 : 163–184, 2004; Mol. Biol. Cell Suppl. 18 : 124, 2007; FASEB J. 21 : 519.5, 2007]. RESULTS: Bioactive edited, modified, redox‐ and metalloregulated small hairpin shRNA [<200 bases] were found and sequenced. By metal ion‐structured 5’ CUG 3’ ‐hairpin loops, they may address homologous domains shared in proteofactors related to [epi]genetic information indexing of the epigenome, growth and metabolic syndrome, termed K/R3H [K/RxxxH], i.e. ‐t/s/x K / R /q/n/hxxx H /y/n/q/e/d/r/kx 7–9 h/xx 7–9 h/xx 5–20 K / R /q/n/e/h‐ with accessory basic [R/K]n, R/K‐zipper, SR/K/RS and/or HxxxH/y/n/q segments and relationship to other canonical domains [HxxxH, ATCUN, CxxxC, fingers, L‐zipper, Rossmann‐fold]. CONCLUSIONS: Such RNA are suitable as bioaptamers for fine tuning tolerance. They are earliest outputs in transcription [~98%], translation [~2%] and in estimated recognition repertoires, superior in diversity / specificity [>~10 17 ] to immune proteins [~10 13 ]. For tolerance, all attributes make them efficient and competent to recognize, address and integrate information flow on all possible molecular shapes back to genomic mechanisms.