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Does oxidative stress play any role in the etiopathogenesis of preeclampsia?
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.986.3
Subject(s) - oxidative stress , preeclampsia , malondialdehyde , glutathione , superoxide dismutase , placenta , antioxidant , medicine , andrology , endocrinology , pathological , fetus , pregnancy , chemistry , biology , enzyme , biochemistry , genetics
Preeclampsia a hypertensive disorder of human pregnany is one of the leading causes of maternal and fetal morbidity and mortality. Its etiology is not fully known. Decreased antioxidants and increased serum levels of lipid peroxides are suggested to be the as pathological factors. However, little is known about oxidative stress marker like malondialdehyde (MDA), antioxidant‐glutathione (GSH) and antioxidant enzyme ‐ the superoxide dismutase (SOD) in the placental tissue. The present study evaluates the status of oxidative stress markers in the placental tissue. Methods: A total of 60 placental samples of which, 30 from women with normal delivery (control group) and 30 from women with preeclampsia (preeclamptic group), were obtained immediately after delivery. The placental tissues were analyzed for MDA, GSH and SOD levels using standard techniques. Results: The levels of MDA were significantly higher in preeclamptic placentas than in normal (12.21± 4.1 vs 4.7± 2.1 nmol/gm tissue, p < 0.0001). In addition, there was significant difference in GSH level of placental tissues in preeclamptic placentas than that of normal placentas (0.46 ± 0.37 vs 1.03 ± 0.43 Umol/gm tissue, p < 0.0001). The SOD activity was lower in preeclamptic placentas than in normal placentas (4.14 ± 2.25 vs 5. 22 ± 2.0 Units/mg tissue protein), but it was not statistically significant (p < 0.055). Conclusion: The study suggests that the oxidative stress may be contributory fact.