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Parvalbumin immuno‐reactive somata in mouse barrels display a wide range of thalamocortical input
Author(s) -
White Edward L.,
Weinfeld Elizabeth
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.974.6
Subject(s) - parvalbumin , neuroscience , postsynaptic potential , neocortex , excitatory postsynaptic potential , biology , cortex (anatomy) , chemistry , inhibitory postsynaptic potential , biochemistry , receptor
Electrophysiological studies indicate that parvalbumin (PV) containing neurons are fast spiking and strongly excited by thalamocortical (TC) afferents (Kawaguchi and Kabota, J. Neurophysiol 70:337, 1993; Beierlein et al. J. Neurophysiol 90:2987, 2003; Swadlow, 25:32, 2003; Bruno and Simons, J. Neurosci. 22:10966, 1975). This is a serial thin section analysis of synapses between degenerating TC afferents and PV‐labeled, non‐spiny neurons in layer IV of mouse PMBSF cortex in which lesion induced degeneration has proven reliable for quantification of TC synapses (White, 1989). 12 PV‐labeled somata (4 mice), of various shapes and sizes, received from 0 to 0.0544 TC synapses/μm2 of somatic membrane examined. We suggest that the PV‐labeled somata clustered at the high end of the range are equivalent to the FS cells described by Sun et al. (J. Neuroscience 26:1219, 2006) that, strongly excited by TC afferents, go on to provide powerful feedforward inhibition of spiny stellate cells. The remaining PV‐labeled somata formed few TC synapses, consistent with the contention (Porter et al., J. Neurosci 21:2699, 2001) that no clear relationship exists between the amount of TC input and the type of calcium binding protein within the postsynaptic neuron. Information on the numbers of TC synapses formed with the dendrites of PV‐labeled cells is needed for a more complete picture. Supported by the generosity of Suzanne B. Zlowtowski