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Different effect of acute heart failure on stepwise frequency bands of QRS complex in electrocardiogram
Author(s) -
Matsushita Shonosuke,
Tokunaga Chiho,
Enomoto Yoshiharu,
Kanemoto Shinya,
Watanabe Yutaka,
Hiramatsu Yuji
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.971.5
Subject(s) - qrs complex , heart failure , cardiology , medicine , electrocardiography
We found that high frequency component of QRS complex in EKG decrease in acute heart failure after open‐heart surgery. It became one of the indexes to recognize degree of heart failure electrically. However, which frequency bands of QRS complex are most sensitive to heart failure has not been identified. To clarify this, relationship between voltage of stepwise frequency bands (1–20Hz, 20–40Hz, 40–80Hz, >80Hz) of QRS complex and left ventricular pressure (LVP) was examined in 4‐minopyridine (4‐AP) induced rat heart failure model. LVP was decreased by use of 4‐AP (from 82+/−23 to 37+/−20 mmHg: p<0.005). Although lower frequency bands (1–20Hz, 20–40Hz) were unchanged, higher frequency bands (40–80Hz, >80Hz) were decreased from 4.1+/−2.0 to 1.6+/−1.4 (mV)^2 (p<0.01), from 3.0+/−1.2 to 0.3+/−0.4 (p<0.0001) respectively when LVP decreased. After recovery of LVP, voltage of high frequency both bands returned to pre‐treatment level. Most sensitive frequency bands to heart failure was bands of >80Hz. Since Ca2+ overload to cardiomyocytes decreased high frequency component of QRS complex from our previous study, elevation of intracellular Ca2+ concentration during heart failure may pivotal role in this phenomenon.