Premium
Severe Effects of Anesthetic Induction Agents in the Cardiovascular Profile of Diabetic Rats.
Author(s) -
Quidgley Jose,
Portilla Peter,
Zalacain Joaquin,
Cruz Nildris,
Crespo Maria J
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.970.32
Subject(s) - medicine , diabetes mellitus , streptozotocin , anesthetic , ketamine , blood pressure , propofol , etomidate , heart rate , anesthesia , glibenclamide , stroke volume , endocrinology
Diabetic patients have a higher incidence of cardiovascular diseases and are more prone to surgical procedures than non‐diabetics. However, there is lack of studies regarding the most appropriate anesthetic induction agent for these patients. In this work, we assessed the cardiovascular effects of the minimal dose required for induction of anesthesia with either propofol (PRO, 50 mg/kg, IP), etomidate (ETO, 20 mg/kg, IP) or ketamine (KET, 100 mg/kg, IP) on Sprague‐Dawley rats 4 weeks after diabetes induction (Streptozotocin, STZ, 65mg/Kg, IP). Age‐matched non‐diabetic rats (CT) were used for comparison. Systolic blood pressure (SBP) and echocardiographic studies including heart rate (HR), stroke volume (SV), and cardiac output (CO) were evaluated. Results demonstrate significant differences between STZ and CT in all studied parameters. KET lowered SBP, SV, HR, and CO in STZ rats by 36.8%, 23.4%, 29.9% and 47.7% respectively when compared to CT (N= 7, P<0.05). In contrast ETO increased SBP by 76.7% (P<0.05) but decreased SV, HR and CO by 17.7%, 34.2% and 48.5% respectively when compared to CT (N= 7, P<0.05). PRO increased SBP by 37.9% (P<0.05) but did not modify HR, SV or CO when compared to CT. These results suggest that diabetes alters the physiological responses to anesthetic induction agents. This study has strong implications for diabetic patients where alterations in their response to these agents are expected.