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Effect of heart failure on cardiac and respiratory variability and cardioventilatory coupling
Author(s) -
Kruper Gregory John,
Fishman Mikkel,
Hoit Brian D,
Chandler Margaret,
Loparo Kenneth A,
Dick Thomas E
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.970.26
Subject(s) - cardiology , medicine , heart rate variability , heart failure , heart rate , respiration , respiratory system , plethysmograph , respiratory rate , blood pressure , cardiac function curve , anesthesia , anatomy
Changes in heart rate (HRV) and respiratory variabilities are associated with worsening heart failure (HF). We hypothesized that changes in non‐linear dynamic properties of respiratory pattern track the development of early HF. In Sprague Dawley rats (n=6, 3 with sham surgery) were implanted with wireless blood pressure (BP) transducers (DSI transmitters) and the left main cardiac artery was ligated. Heart rate (HR), BP and respiration was monitored simultaneously by placing a plethysmograph on the DSI‐receiver. Animals were exposed to: 21%, 100% and 8% O 2 each wk following surgery. Animals were echoed at 6 wk to assess cardiac function. Breath‐to‐breath variability (Ti and Te) was assessed by systematically applying non‐linear analytical tools to epochs of stationary data, and compared the results to 19 surrogate data sets, in which the auto‐correlation function was preserve but the time dependent properties of the data set were destroyed. Mutual information increased and sample entropy of the interval decreased from 3 to 8 wks post‐surgery in HF animals compared to animals those received sham surgery. These changes in variability were especially apparent when animals were breathing a hypoxic mixture. These preliminary data suggest that nonlinear sources of breathing variability are sensitive to cardiac performance decrease even during the early stages of HF (HL‐080318).