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How geometric, electrical and contractile alterations effect cardiac function in the failing heart
Author(s) -
Kerckhoffs Roy,
Mulligan Larry,
Omens Jeffrey,
McCulloch Andrew
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.970.21
Subject(s) - cardiology , left bundle branch block , dilation (metric space) , heart failure , medicine , stroke volume , cardiac function curve , ejection fraction , mathematics , geometry
In heart failure patients with left bundle branch block (LBBB) global and regional cardiac function is reduced. The goal of this study was to investigate how geometric, electrical and contractile alterations as they occur in heart failure with LBBB contribute to changes in global and regional function, using a numerical cardiovascular model. A 3D ventricular model was coupled to a closed circulation (with no mitral regurgitation). Cardiac cycles were simulated for all combinations of 4 altered input parameters (dilation, slower conduction, reduced peak fiber stress, longer fiber force twitch). Contributions of alterations and their interactions to cardiac global (stroke volume, SV) and regional function (CURE index of mechanical synchrony: 0