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Varied functions of small, non‐coding RNAs in bacteria
Author(s) -
Storz Gisela,
Opdyke Jason A.,
Fozo Elizabeth M.,
Waters Lauren S.,
Kawano Mitsuoki,
Zhang Aixia
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.97.2
Subject(s) - complementarity (molecular biology) , small nucleolar rna , computational biology , microrna , non coding rna , biology , rna , long non coding rna , translation (biology) , small rna , bacteria , messenger rna , genetics , gene
In recent years, a combination of computational and molecular approaches has led to the identification of >80 small, noncoding RNAs in E. coli. More and more small RNAs are also being discovered in other bacteria. Most of the characterized small RNAs have been shown to act by basepairing at the 5′ or 3′ ends of mRNAs. In some cases the region of complementarity is extensive while in other cases only short regions of complementarity are required for regulation. Basepairing can lead to increased or decreased message stability or can block or facilitate translation. The mechanisms by which basepairing between small RNAs and their mRNA targets leads to these varied regulatory outcomes will be discussed. Supported by the Intramural Program of the NICHD.