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Limb‐specific vascular reactivity and ischemic reperfusion: sex differences?
Author(s) -
Nishiyama Steven Keita,
Wray David Walter,
Berkstresser Kimberley A,
Harris Ryan A,
Richardson Russell S
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.967.14
Subject(s) - medicine , brachial artery , popliteal artery , cardiology , cuff , peripheral , artery , occlusion , anatomy , surgery , blood pressure
We sought to investigate vascular reactivity and ischemic reperfusion (IR) characteristics in peripheral conduit arteries of the upper and lower extremities in men and women. In thirty young, healthy volunteers ( n = 15 men, 28 ± 2 yrs; n = 15 women, 23 ± 1 yrs) we utilized ultrasound Doppler to evaluate IR and flow‐mediated dilation (FMD) following 5‐min supra‐systolic cuff occlusion in both the arm (brachial artery, BA) and leg (popliteal artery, PA). Cumulative IR (area under the curve, AUC) normalized for muscle mass was greater in the arm compared to the leg ( P < 0.05), but revealed no sex‐related differences in either arm (men: 40 ± 3 ml/100g; women: 42 ± 4 ml/100g) or lower leg (men: 12 ± 3 ml/100g; women: 15 ± 2 ml/100g). When FMD (% change diameter) was normalized for the shear rate AUC, the leg (PA) of both men and women revealed a significantly greater FMD for a given shear rate than the arm (BA) (PA: 9.7 ×10 −4 ± 0.1 ×10 −4 and BA: 3.6 ×10 −4 ± 0.3 ×10 −4 % Δ / s −1 •s, P < 0.05; female group: PA: 8.1 ×10 −4 ± 1.7 ×10 4 and BA: 3.4 ×10 −4 ± 0.5 ×10 −4 % Δ/s −1 •s, P < 0.05). However, there were no sex‐related differences in FMD per unit of shear rate in both limbs. These findings confirm vascular limb‐differences in a female group, while also revealing no sex‐related difference in functional vascular characteristics (IR and FMD) in either limb.