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Electron‐dense vesicles in the endothelium of human extremity veins
Author(s) -
Gõsi Gergely,
Raffai Gábor,
Fehér Erzsébet,
Acsády György,
Monos Emil
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.964.38
Subject(s) - vesicle , endothelium , microcirculation , vein , medicine , anatomy , chemistry , endocrinology , cardiology , membrane , biochemistry
Secretory type electron‐dense vesicles containing vasoactive agents (endothelin, PDGF) were found in the endothelium of rat saphenous vein in high frequency, that decreases after long‐term orthostatic stress (Raffai et al. J Vasc Res 42(2), 157–64 (2005)). The purpose of this study was to identify these structures and to measure their quantity in human extremity veins that might play a role in gravitational adaptation via altering vascular tone, vascular permeability, and growth. Veins were collected from twelve patients, who underwent vascular surgery (upper/lower extremity n=5/7). Digitalized electron micrographs were used to measure vesicular density. Considering all vein samples, the microvesicular area (relative to the cross‐sectional area of the endothelial cells) was 4.5±1.36%. As our preliminary observations show, the amount of electron‐dense vesicles in the samples of the upper extremity was 2.30±0.88%, while that of the lower extremity was 6.07±2.11% (n.s.). Similarly to our observations, a substantial amount of secretory type microvesicles can be found also in the endothelium of human extremities. The difference, seen as a tendency, in vesicle content of upper and lower extremities suggests their possible role in orthostatic adaptation. There might be dependence between vesicle content and the orthostatic lifestyle. (Research grants: OTKA T‐042670/2003, ETT 128/2006, and TP‐163/2005)

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