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Chromatin Responses to DNA Damage
Author(s) -
Shen Xuetong,
Morrison Ashby
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.96.1
Subject(s) - chromatin remodeling , chromatin , microbiology and biotechnology , dna damage , histone , biology , dna repair , histone modifying enzymes , chromatin structure remodeling (rsc) complex , genome instability , histone code , chia pet , dna , genetics , nucleosome
Proper repair of DNA damage is critical in preventing genome instability and carcinogenesis. While the role of ATP‐dependent chromatin remodeling in transcription is well established, a link between chromatin remodeling and DNA repair has remained elusive. We have found that the evolutionarily conserved INO80 chromatin remodeling complex directly participates in the repair of a double strand break (DSB) in yeast. Our findings reveal a new role of ATP‐dependent chromatin remodeling in nuclear processes and suggest that an ATP‐dependent chromatin remodeling complex can read a DNA repair histone code. We have also found recently that a subunit of the INO80 complex is phosphorylated in an ATM/ATR‐dependent fashion in response to DNA damage, and the phosphorylation events modulate DNA checkpoint pathways. Thus, chromatin responses to DNA damages involve complex changes in both histones and complexes that regulate chromatin.