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Voluntary exercise training attenuates the cardiovascular and brain responses to severe hemorrhage in conscious rats
Author(s) -
Ahlgren Joslyn K.,
Hayward Linda F.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.957.14
Subject(s) - sed , medicine , blood pressure , heart rate , mean arterial pressure , shock (circulatory) , hemodynamics , endocrinology , cardiology , anesthesia
Exercise training has been shown to be beneficial for various cardiovascular pathologies. This study was performed to test the hypothesis that chronic exercise is also beneficial to cardiovascular function during severe hemorrhage (HEM). Adult male rats were pair‐housed in cages with running wheels (n=6; exercise [EX] group) or without (n=6; sedentary [SED] group). After 6 weeks, all rats underwent a 15‐min HEM during which 30% of the estimated total blood volume was removed. Mean arterial pressure (MAP) and heart rate (HR) were recorded. 90 min post‐HEM, animals were anesthetized and transcardially perfused and brains processed for c‐Fos immunoreactivity. No statistical difference in HR was seen between groups during HEM. In contrast, MAP in SED rats dropped to 47% of baseline following HEM, while EX rats dropped only 25% (P<0.01). Several subnuclei within the lateral parabrachial nucleus (LPBN), a region known to modulate the response to HEM, displayed significantly less Fos‐positive cells in EX compared to SED animals. These data demonstrate that voluntarily active rats are better able to defend blood pressure during HEM, attenuating the severity of the cardiovascular decline associated with hypotensive shock. Furthermore, the benefits provided by exercise may have a central component involving LPBN area neurons. AHA‐53426 (LFH) & 65810 (JKA)