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Interactions between gonadal steroids and neonatal caffeine exposure on HVR in adult male rats
Author(s) -
Bairam Aida,
kinkead Richard,
Lajeunesse Yves,
Fournier Stéphanie,
Montandon Gaspard,
Joseph Vincent
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.955.4
Subject(s) - caffeine , hypoxia (environmental) , endocrinology , medicine , respiratory system , apnea of prematurity , apnea , hormone , testosterone (patch) , physiology , pregnancy , biology , chemistry , gestational age , oxygen , organic chemistry , genetics
Caffeine is commonly used to treat apnea in newborn infants, but the long‐term consequences of this treatment are poorly understood. We previously showed that neonatal caffeine treatment induces long lasting changes on respiratory control in adult male rats but not in females. To test the interaction of neonatal caffeine treatment and sexual hormone on respiratory pattern, adult male and female rats, that received by gavage either caffeine (15mg/kg/day – postnatal days 3–12) or water (control) were sham‐operated or gonadectomized. After 14 days of recovery, ventilatory parameters were measured under normoxia and in response to moderate hypoxia (12% O 2 – 20 min). In sham males, a significant interaction (treatment x hypoxia) was obtained for the increase in respiratory frequency (p<0.001) and the decrease in inspiratory time (p<0.01) in hypoxia. No interaction was obtained in gonadectomized rats. In females, no interaction between hypoxia and nicotine was observed in sham or ovarectomized rats. This suggests that endogenous circulating testosterone in adult males is necessary to reveal the alterations induced by caffeine on respiratory control. Supported by CIHR.