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High salt intake enhances sympathetic modulation in the rat.
Author(s) -
Farah Vera Azevedo,
Fiorino Patricia,
Roque Andre Prevides,
Martins André Alves,
Fonteles Manassés Claudino
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.953.1
Subject(s) - blood pressure , heart rate variability , medicine , pulse pressure , analysis of variance , heart rate , endocrinology , zoology , cardiology , chemistry , biology
There is a significant association between salt intake and high blood pressure that could be related to alterations in autonomic modulation of cardiovascular system. The purpose of this study was to evaluate in rats the cardiovascular function induced by high salt intake. Male Wistar rats (n=5, each group) were divided in: 1) Control group (CG), without treatment and 2) Salt treatment (SG), salt added to the drinking water (1%) during 10 days. Arterial pressure (AP) was recorded and processed with a data acquisition system (2kHz sampling frequency). Systolic arterial pressure (SAP) and pulse interval (PI) time series were submitted to autoregressive spectral analysis to determine SAP and PI variability in time and frequency domains in order to evaluate autonomic influences on the circulation. AP was higher in SG (119 ± 2.2 mmHg) than in CG (104 ± 1.5 mmHg), whereas heart rate was not changed. There was an increase in SAP variance and its low frequency domain (9.3 ± 0.5 vs. 16.5 ± 1.5 mmHg2, variance and 6.3 ± 9.8 ± 0.5 mmHg2, LF, CG vs. SG). High salt intake also increased PI variability analyzed by either time (12 ± 0.8 vs. 27 ± 3.2 ms2, CG vs. SG) or frequency domains (9 ± 0.6 vs. 17 ± 1.5 ms2, CG vs. SG). The key findings of the present study were that high salt intake increased blood pressure that is associated with increased sympathetic modulation described herein. Financed by CNPq and MackPesquisa‐Brazil.