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Oxytocin reduces pressor and tachycardic response to the alarming stress in the infarcted rats
Author(s) -
SzczepanskaSadowska Ewa Krystyna,
Wsol Agnieszka,
Kowalewski Stanislaw,
CudnochJedrzejewska Agnieszka,
Dobruch Jakub
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.952.2
Subject(s) - medicine , oxytocin , blood pressure , ventricle , heart rate , myocardial infarction , saline , anesthesia , femoral artery , sham surgery , mean arterial pressure , cardiology , endocrinology , alternative medicine , pathology
It is well known that oxytocin (OT) is one of the neuropeptides involved in regulation of behavioral responses to stress. OT may also play a role in central regulation of blood pressure. The purpose of the study was to investigate the role of OT in central cardiovascular control in the infarcted rats. The experiments were performed on conscious male SD rats subjected either to the myocardial infarction or sham surgery. Both groups were instrumented with the left cerebral ventricle (LCV) for central infusions and with the femoral artery catheter for mean arterial blood pressure (MABP) and heart rate (HR) recording. Four weeks after the cardiac surgery the sham and infarcted rats were divided into two groups receiving either LCV infusions of 0.9% NaCl or OT. MABP and HR were recorded during 40 min of rest and during and after the air jet stress. Resting MABP and HR were not affected by OT or 0.9% NaCl infusions. During saline infusion MABP and HR responses to air jet were significantly greater in the infarcted than in the sham rats. Infusion of OT significantly reduced both responses in the infarcted but not in the sham rats. The results provide evidence that oxytocin is able to normalize exaggerated cardiovascular responses to stress during the post‐infarct state. This study was supported by the Medical University of Warsaw – grants 1MA/NM1/06, 1MA/N/07.