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Preservation of renal function in the obese Zucker rat by antioxidant diet
Author(s) -
Inman Sharon Ruth,
Jackson Edwin,
Oshogwemoh Olusayo,
Slyvka Yuriy,
Nowak Felicia V
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.944.2
Subject(s) - medicine , endocrinology , renal function , diabetes mellitus , blood pressure , obesity , type 2 diabetes
Type 2 diabetes accounts for 90–95% of all diabetes mellitus and is the worldwide leading cause of end‐stage renal disease (ESRD). The obese Zucker rat model of Type 2 diabetes was used to determine the gender differences of ESRD and effect of administration of an antioxidant (AO) diet on the progression of ESRD. Male and female obese Zucker rats (fa/fa) were studied at 13 and 20 weeks of age on regular (REG) and AO diets.Disease progression was determined by blood glucose, mean arterial pressure (MAP), and glomerular filtration rate (GFR). The AO diet had effects on GFR, MAP and blood glucose in female rats. GFR in 20 week old females on the AO diet was higher than in rats on the REG diet (0.346 ± 0.098 vs 0.053± 0.031 ml/min, p=0.028). This difference was not observed in males. MAP in females at 20 weeks was lower on the AO diet than on the REG diet (121.5±5.8 vs 146.2±1.7 mm Hg, p=0.02). The data also suggest that the AO diet lowers blood glucose in 13 week female rats (371.3±81.1 vs 688.3±31.9 mg/dl, p=0.005). A sex difference was also observed. MAP was higher in males at 20 weeks than in females, on both AO and REG diets. Conclusion: An AO diet preserves several important parameters in obese Zucker rats, including GFR, MAP and blood glucose. The effect was more significant in females. Supported by NIH R15 DK073066 to SRI and FVN