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Selective Estrogen Receptor Agonists Enhance Blood Pressure, Thromboxane and Prostacyclin in Aortic Coarctation‐Induced Hypertensive Female Rats
Author(s) -
Sellers Minga,
Xu Feng,
Stallone John
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.941.14
Subject(s) - medicine , endocrinology , prostacyclin , thromboxane , ovariectomized rat , chemistry , thromboxane receptor , estrogen , blood pressure , estrogen receptor , basal (medicine) , thromboxane a2 , receptor , platelet , diabetes mellitus , cancer , breast cancer
Previously, we reported that estrogen receptors (ERα, ERβ) exert differing effects on mesenteric arterial reactivity to vasopressin (VP) and that estrogen enhances constrictor prostanoids by upregulating thromboxane synthase and cyclooxygenase‐2 message in rat aorta. We measured mean arterial blood pressure (BP), thromboxane (TXA 2 ) and prostacyclin (PGI 2 ) release by mesenteric arterioles (200 μm) in normo‐ and aortic coarctation‐induced hypertensive (NT and HT) Sprague‐Dawley female rats that were intact (INT), ovariectomized (OvX), or OvX + treated with ER‐selective agonists DPN (ERβ) or PPT (ERα), 100μg/rat/day (13–15 days). BP in PPT HT (180±4 mmHg) is similar to INT HT (183±4) and DPN HT (182±4). BP is lowest in OVX HT (153±3). BP in NT did not differ (mean = 127±1). Basal TXA 2 was lowest in OVX and DPN NT (51 ± 20; 40 ± 7 pg/mg tissue/45 min), while INT or PPT NT are higher (93 ± 1; 93 ± 10). HT increases basal TXA 2 threefold. VP (10 −8 ) increases TXA 2 least in DPN NT (79 ± 11) vs INT NT (108 ± 1), OVX NT (137 ± 33) or PPT NT (134 ± 31). HT increases VP stimulated TXA 2 . PPT HT increased the most (643 ± 137) vs INT HT (415 ± 46), OVX HT (277 ± 56) or DPN HT (334 ± 33). PGI 2 shows similar trends in all groups; PPT enhanced basal and VP stimulated PGI 2 the most. These data suggest that ERα enhances TXA 2 and PGI 2 to a greater extent than ERβ. The increased PGI 2 does not afford protection to BP in PPT HT. (Supported by NIH: HL‐080402)