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Pharmacological Intervention Studies Reveal the Protective Role of Coronary Endothelium during the Development of Cardiac Hypertrophy
Author(s) -
Sun Xiaowei,
Ku David D.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.914.2
Subject(s) - medicine , cardiology , rosuvastatin , right ventricular hypertrophy , muscle hypertrophy , ventricle , cardiac function curve , heart failure
Extensive studies have shown that chronic heart failure/hypertrophy often accompanied by abnormalities in coronary endothelial (CEC) function. In a selective right ventricular hypertrophy (RVH) rat model we noted for the first time that the right CEC function was significantly increased prior to the development of RVH, while the left coronaries in the unaffected left ventricle was not altered. As cardiac hypertrophy developed, marked depression of CEC function was noted. To further investigate the significance of CEC function during the development of RVH, we studied the effects of both early (prevention) and late (rescue) treatments with a natural product (garlic) or a standard statin (rosuvastatin, RS). Oral treatment with 1% garlic supplemented diet either 1 day before or 1 day after the induction of RVH showed significant preservation of CEC function and prevention of RVH. Similar treatments with garlics without its active ingredient, allicin, failed to produce a protective effect. Oral treatment with a water‐soluble HMG‐CoA reductase inhibitor, RS, 1 week before as well as 1 week after the induction of RVH also effectively prevented CEC dysfunction and RVH. Conversely, inhibition of CEC function with L‐NAME treatment exacerbated the development of RVH. Taken together, results of our studies demonstrate that modulation of CEC function provides a novel approach for the management of cardiac hypertrophy.