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Observational studies of Dopamine D2‐family agonists in squirrel monkeys
Author(s) -
Desai Rajeev I,
Connolly Jennifer,
Bergman Jack
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.904.4
Subject(s) - partial agonist , catalepsy , scratching , chemistry , pharmacology , agonist , dopamine receptor d2 , dopamine , haloperidol , medicine , receptor , biochemistry , physics , acoustics
Dopamine D 2 ‐family (D 2 ) agonists and antagonists produce dose‐related increases in, respectively, scratching and catalepsy‐associated behavior (CAB) in squirrel monkeys. The effects of D 2 ligands on observable behavior were further compared in the present study. Results show that D 2 full agonists [(+)‐PHNO, R(−)‐NPA, quinelorane, PD 128907 and 7‐OH‐DPAT] produced dose‐dependent increases in scratching, with effects that varied in magnitude among drugs [R(−)‐NPA ≈ (+)‐PHNO (>35% of session) > quinelorane ≈ PD 128907 ≈ 7‐OH‐DPAT (<25%)]. D 2 partial or mixed‐action agonists [terguride (TER), preclamol (PREC), talipexole (TAL), roxindole (ROX), aripiprazole (ARIP)] did not significantly increase scratching. Results also show that, like haloperidol (HAL), TAL, TER, ARIP and ROX produced dose‐related increases in CAB. HAL, TAL, and TER produced high levels of CAB (65–99% of session), whereas the mixed‐action D 2 partial agonists ROX and ARIP produced lesser levels of CAB (<40%). The D 2 full agonists (+)‐PHNO, 7‐OH‐DPAT and PD 128907 produced no evidence of CAB. Although the roles of D 2 subtypes in agonist‐induced scratching or of intrinsic activity in CAB are not well understood, these behavioral endpoints serve as quantifiable measures of D 2 receptor activation or blockade in primate species. (supported by NIH/NIDA RO1‐03774, RO1‐10566)