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PREDICTIVE FACTORS OF DYSPLASIA ON COLONIC POLYPS
Author(s) -
Ramos Rui,
Duarte Patricia,
Pereira Marta,
Vicente Celia,
Medeiros Jose,
Cabrita Antonio,
Casteleiro Carlos
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.898.29
Subject(s) - dysplasia , medicine , gastroenterology , adenoma , tubular adenoma , colonoscopy , splenic flexure , sigmoid colon , colorectal cancer , cancer , rectum
The clinical importance of colonic polyps resides in the risk of adenoma progression to colon cancer (the “adenoma‐carcinoma” sequence). Objectives: To evaluate the presence of dysplasia on colon polyps and identify factors which are predictive of high‐grade changes. Material and methods: Histopathologic studies were carried out on 357 polyps, excised from 334 patients, out of 1423 colonoscopies performed in 2006. Results: Most (77.5%) polyps were distal to the splenic flexure, and the majority was found in the sigmoid colon; 71.8% were tubular adenomas. Low‐grade changes were found in 22.5% of the adenomas, while 77.5% showed high‐grade dysplasia. Only 6.4% of polyps were larger than 2 cm, while 60.1% measured less than 1 cm; 11.2% of the latter had high‐grade dysplasia. Conclusions: 1 ‐ All polyps should be excised, regardless of their size, since high‐grade dysplasia can be found in more than 10% of small polyps; 2 – High‐grade dysplasia was more likely in polyps larger than 1 cm, and especially those larger than 2 cm; 3‐ High‐grade dysplasia was also more frequent in distal, villous and stalked polyps.