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Effect of ozone boluses on the lung function of smokers
Author(s) -
Bates Melissa Lowe,
Brenza Timothy M.,
BenJebria Abdellaziz,
Ultman James S.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.897.14
Subject(s) - spirometry , inhalation , bolus (digestion) , medicine , anesthesia , ozone , cardiology , zoology , chemistry , asthma , organic chemistry , biology
During continuous exposure to ozone (O 3 ), smokers have failed to experience the decrements in forced spirometric parameters that have been well‐established for comparable non‐smokers. We hypothesized that these differences in response are due to differences in the longitudinal distribution of O 3 uptake. We measured the longitudinal distribution of O 3 uptake using the bolus inhalation method but found no difference between populations of 29 non‐smokers (17M, 12F) and 30 smokers (19M, 11F, 4±4 pack‐years). We also measured FEV 1 by spirometry and the normalized slope of the alveolar plateau (S N ) by capnography. Smokers experienced a significant change in S N (8.1 ± 3.2%, p=0.02) and a small, but significant change in FEV 1 (−1.3 ± 0.6%, p=0.03) after inhaling between 75 and 120 20‐mL O 3 boluses with an average concentration of 1 ppm. Nonsmokers did not exhibit such responses. We conclude that during a transient exposure to O 3 , smokers may be differentially responsive to O 3 in spite of the similarity of their O 3 uptake distribution to that of non‐smokers.