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Effects of a soy protein‐soluble fiber beverage in subjects with ABCG5/8 polymorphism with mild hypercholesterolemia.
Author(s) -
GuevaraCruz Martha,
Torres Nimbe,
Tovar Armando R
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.892.1
Subject(s) - hyperlipidemia , cholesterol , soy protein , medicine , endocrinology , saturated fat , lipoprotein , allele , polymorphism (computer science) , food science , chemistry , biology , biochemistry , gene , diabetes mellitus
The ATP binding cassette G5/8 (ABCG5/8) polymorphisms have been postulated to play a role in response to dietary cholesterol. The objective of this study was to determine whether the combination of soy protein diet and soluble fiber in a low saturated fat diet may reduce total and LDL‐cholesterol, and to determine if the responsiveness to the diet was associated with the presence of the polymorphisms of the ABCG5 (C1950G), or ABCG8 (D19H) genes in subjects with hyperlipidemia. SUBJECTS: 51 subjects with an average age of 43 ± 9 y were studied, with serum total cholesterol concentration of 260 to 330mg/dl. Subjects consumed a low saturated fat diet (LSFD) according to the ATP III program for four weeks. Then, patients started to eat a LSFD with a soy protein‐soluble fiber beverage that provided 25g of soy protein and 15 g of soluble fiber for two months. Each month serum cholesterol (TC), triglycerides (TG), high‐ density lipoprotein‐cholesterol (HDL) and low density lipoprotein‐cholesterol (LDL) were determined. RESULTS: Allele frequencies (wild‐type, variant) were C1950G (0.29, 0.40) and D19H (0.90, 0.09). Both genotypes were distributed according to the Hardy‐Weinberg equilibrium. There was a significantly reduction in TC and TG with the protein‐soluble fiber beverage (p< 0.0001) regardless of the polymorphisms, however patients with the ABCG8 D19H variant had lower serum TC, TG and LDL levels. CONACYT grant C01‐016.