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Ingestion of casein and safflower oil, not soy protein and palm oil attenuates renal damage in hyperuricemic rats
Author(s) -
Lo HuiChen,
Cheng ChunHsiang,
Yang Yu
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.891.7
Subject(s) - hyperuricemia , allopurinol , uric acid , soy protein , ingestion , casein , chemistry , food science , blood urea nitrogen , excretion , gout , corn oil , endocrinology , medicine , kidney , biochemistry
Epidemiological studies indicated that there is a high prevalence of hyperuricemia in Taiwanese, especially in elderly and male aborigines. Using oxonic acid, a uricase inhibitor, and uric acid (UA) induced hyperuricemic rats, we investigated the effects of different dietary protein and lipid on UA excretion and renal damage. Male Wistar rats with hyperuricemia were fed with casein or soy protein as protein source and safflower oil or palm oil as lipid source for 8 weeks. Hyperuricemic rats with or without allopurinol treatment (150 mg/L in drinking water) and normal rats fed with AIN 93M diet, which composed of casein and corn oil, were also included. After 8 weeks, hyperuricemia‐induced decrease in feed efficiency was significantly improved by ingestion of casein and safflower oil; the induced increases in serum UA was significantly attenuated by allopurinol treatment and ingestion of soy protein and safflower oil; whereas the induced increase in blood urea nitrogen was augmented by palm oil ingestion. Moreover, animals ingested with casein and safflower oil, not soy protein and palm oil or allopurinol treatment had significantly attenuated hyperuricemia‐associated tubulointerstitial nephritis, crystals, and fibrosis in the kidneys. Our results suggest that vegetated diet with soy‐based protein and plant‐based saturated fatty acids might not be appropriate for patients to reduce the deleterious effects of hyperuricemia.