Premium
Soy protein diet protects against liver steatosis using DMBA‐Induced mammary tumors in an ovariectomized obese zucker rat model
Author(s) -
Hakkak Reza,
Saeid Shaaf,
Talley Lori,
Fuchs George,
Korourian Soheila
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.891.3
Subject(s) - steatosis , medicine , endocrinology , fatty liver , ovariectomized rat , dmba , lipogenesis , soy protein , obesity , adipose tissue , estrogen , pathology , cancer , carcinogenesis , disease
Human and animal studies have suggested that obesity can play important role in promotion of fatty liver. Recently, we have reported that short‐term soy protein diet can reduce fatty liver. The main objective of this experiment was to investigate the long‐term effects of obesity and soy diet on liver steatosis using 7,12‐dimethylbenz(a)anthracene (DMBA)‐Induced mammary tumors in an ovariectomized obese zucker rat model. treatment. Ovariectomized lean (n=56) and Obese (n=60) Zucker rats were maintained on either casein or soy protein diet from one week before and until 155 days after DMBA treatment. All rats were orally gavaged at age 50 days with 65 mg/kg DMBA. Our results demonstrated obesity caused a significant increased on liver weight (P<0.05) and soy diet reduce liver weight in lean and obese group (P<0.05). Obesity caused a significant increase in fatty liver steatosis with rats fed casein diet had marked steatosis with small foci of mononuclear infiltration (P<0.05) but soy‐fed lean (1.00±0.0) and obese (3.20±0.26) rats significantly had lower steatosis than casein‐fed lean (1.96±.16) and obese (4.42±.10) rats. Our results suggest that long‐term dietary soy treatment can protects against liver steatosis in lean and obese ovariectomized animals. The mechanisms responsible for increasing fatty liver steatosis in obese rats are under investigation.