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Investigating potential anti‐diabetic effects of specific soy isoflavones and metabolites in female obese Zucker rats
Author(s) -
Banz William J,
James H Bryce,
Ajuwon Kolapo M
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.889.10
Subject(s) - equol , daidzein , endocrinology , medicine , isoflavones , genistein , triglyceride , chemistry , metabolite , soy protein , diet induced obese , insulin , cholesterol , insulin resistance , food science
The purpose of this study was to investigate possible anti‐diabetic effects of the soy isoflavone, daidzein and its metabolite equol in an insulin resistant rodent model. Female obese Zucker rats were randomly assigned to four groups for 11 weeks: casein control (C), injected daidzein (CD), injected equol (CE), and high isoflavone soy protein (H). To bypass GI modification, daidzein and equol were injected and not orally administered. At week 9 animals were subjected to an oral glucose tolerance test (OGTT). At and subsequent to sacrifice, physiological, biochemical, and molecular parameters were examined. Animals on the H diet gained significantly more weight and exhibited a significant increase in food intake when compared to all other groups and also had significantly lower liver weight versus C, CD and CE groups. Additionally, the H animals demonstrated a significantly lower non‐fasted blood glucose level versus the CD and CE groups and the same trend (P<0.07) was observed versus the C group. However, the OGTT did not reveal a significant improvement in glucose tolerance between groups. There was a significant decrease in cholesterol and increase in triglyceride levels in the H group compared to all other groups. Insulin levels were not significantly different between groups. Overall, these results demonstrate differential responses to soy and specific injected soy components and metabolites.