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Effect of long‐term intake of natural and artificial sweeteners in rats
Author(s) -
TovarPalacio Claudia,
DurándeBazúa Carmen,
Tinajero Claudia Martínez,
GonzalezFilomeno Esteban,
GarciaGomez Rolando,
ConstantinoCasas Fernando,
Gracia Isabel
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.888.6
Subject(s) - sucralose , artificial sweetener , aspartame , sucrose , fructose , high fructose corn syrup , food science , weight gain , ingestion , body weight , chemistry , sugar , biology , endocrinology , biochemistry
The use of sugar substitutes has been increased but its use is controversial. The aim of the present work was to study the effect of different natural and artificial sweeteners on obesity promotion and abnormalities due to lipids in the liver and heart. An experimental design using five nine‐rats groups was established using two natural and two artificial sweeteners during 73d: 1 Fructose 15%; 2 Sucrose 10%; 3 Aspartame 0.3%; 4 Sucralose 0.19%; and 5 Water as control. All animals received a standard diet ad libitum . Body weight, food and water intake were measured three times a week. Rats were sacrificed and heart and liver were removed for histological analysis. Results indicated that long‐term fructose intake in water promoted the highest weight gain in the rats, as well as the highest increase in pericardic tissue. Rats that consumed sucrose, although the ingestion of water volume was the highest, they had the lowest food consumption, and the lowest body weight gain. Animals on artificial sweeteners, showed the highest food intake and the pericardic fat areas were much higher than control groups. These experiments show a direct relationship of gain weight, alterations in food intake and alterations heart and hepatic histology of rats on natural and artificial substances.