Premium
High carbohydrate diets increases the expression of SREBP‐1 in kidney
Author(s) -
TovarPalacio Claudia,
MirandaCenteno Natalia,
Ortiz Victor,
PalaciosGonzalez Berenice,
Cruz Cristino,
Palacio Armando R Tovar,
Torres Nimbe,
CorreaRotter Ricardo
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.888.5
Subject(s) - fructose , sucrose , kidney , carbohydrate , endocrinology , medicine , biology , lipid metabolism , chemistry , carbohydrate metabolism , food science
It has been demonstrated that consumption of high carbohydrate diets are involved in the development of obesity. However, it is not know whether the consumption of specific type of carbohydrates alter lipid metabolism in kidney, and this in turn affect kidney function. Thus the aim of this work was to study whether addition of high fructose or sucrose diets regulates differentially SREBP‐1 expression in kidney, and the metabolic changes occurring in kidney function. Thus, male Wistar rats were fed 60% fructose or sucrose diet for 180d. Weigh gain and food intake were similar. Kidney weight was higher in the fructose group in comparison with sucrose group. However, SREBP‐1 mRNA abundance was similar between both groups, but it was higher that the control groups. In addition, both groups showed higher TNFα expression than the control groups. Interestingly, fructose diet produced the appearance of microcalcifications. These results indicate the high carbohydrates diets affect kidney function.