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Influence of Lean and Fat mass on Bone Mineral Content in Asian and White Adolescent Girls
Author(s) -
Daida Yee Yihe,
Novotny Rachel,
Vijayadeva Vinutha,
Grove John,
LeMarchand Loic
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.883.5
Subject(s) - lean body mass , pubic hair , endocrinology , medicine , fat mass , chemistry , body mass index , body weight
A high BMI has been associated with increased bone mass. However, BMI does not differentiate between lean and fat mass. The purpose of this study is to examine the influence of dual‐energy x‐ray fat and lean mass on total bone mineral content (TBMC), among Asian and White adolescent girls. Girls were 9–14 y at visit 1, and 11 to 16 y at visit 2. TBMC was regressed on bone area, age, Tanner pubic hair stage, physical activity, dietary energy, protein and calcium intakes, percent Asian ancestry, and fat and lean mass. Age, pubic hair stage, Asian ethnicity and lean mass were positively associated with TBMC, while height and fat mass were negatively associated with TBMC. When fat mass was removed from the model, age, pubic hair stage, Asian ethnicity and lean mass were positively associated with TBMC, height was negatively associated, and dietary calcium intake was marginally associated with TBMC. When lean mass was substituted for fat mass in the model, pubic hair stage and Asian ethnicity were positively associated with TBMC. Age and calcium intake were marginally associated with TBMC while height was negatively associated. The interaction (cross product of lean and fat mass) was added to the first model and was highly significant and positive, meaning that the effect of lean mass was greater among girls with more fat mass. These findings suggest that lean mass, fat mass and their interaction are important influences on bone mass.