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Serum IGF‐1 and IGFBP‐3 differences between Hutterite and Non‐Hutterite populations
Author(s) -
Beare Tianna,
Donnelly Kevin,
Clapper Joan,
Wey Howard,
Binkley Teresa,
Specker Bonny
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.883.11
Subject(s) - demography , growth hormone , gerontology , medicine , hormone , psychology , biology , sociology
Hutterites, an Anabaptist religious group believing in isolated communal living and self‐sufficiency, are shorter yet have larger bone diameter for their height than non‐Hutterites. A polymorphism in the growth hormone receptor gene has been identified in Hutterites. The purpose of this study was to determine whether circulating levels of serum IGF‐1 differed between Hutterites and non‐Hutterites. Fasting serum IGF‐1 was measured in 217 Hutterites and 127 non‐Hutterites aged 20–66 years who were participants of the South Dakota Rural Bone Health Study. Hutterites had higher IGF‐1 than non‐Hutterites (170 ± 5 vs. 117 ± 6 ng/ml, p<0.001, respectively), yet IGFBP‐3 concentrations were similar (5078 ± 135 vs. 5332 ± 237, p=0.4). Differences remained significant controlling for sex, age, weight, height, activity levels, and protein intake (lsmeans 162 ± 4 vs. 133 ± 6 ng/ml, p<0.001, Hutterite vs. non‐Hutterite). There was an association between IGFBP‐3 and IGF‐1 among non‐Hutterites (r=0.83, p<0.001), but not among Hutterites. The reason for IGF‐1 differences among Hutterites and non‐Hutterites is not known, but may be associated with the bone differences that have been observed. Supported by NIH R01 AR47852.