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Metabolic Syndrome, Type 2 Diabetes and Controls: Comparisons and Contrast
Author(s) -
Hubbard Richard W.,
Westengard James,
Guthrie George
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.879.6
Subject(s) - medicine , type 2 diabetes , metabolic syndrome , vitamin d deficiency , vitamin d and neurology , endocrinology , blood pressure , analysis of variance , diabetes mellitus , bonferroni correction , cohort , parathyroid hormone , gastroenterology , obesity , mathematics , statistics , calcium
These metabolic comparisons were from a highly health motivated, self‐selected cohort (ages16–88) composed of four definable categories: Metabolic Syndrome (MS) (n=67), Type 1 (n=16) and Type 2 (n=155) Diabetics and Controls (n=123). The biological assays were performed at Quest‐Nichols Diagnostics. Statistical analysis was performed by one‐way ANOVA, with Bonferroni adjusted probabilities for multiple comparisons (Systat ver.10; SPSS Inc., 2000). The MS subjects show significantly higher Chol/HDL ratio (p= 0.028) and diastolic blood pressure (0.0004) while the Type 2 diabetics had significantly higher Hbg A1C (p< 0.00005) and higher fasting blood sugar (p<0.00005) values. The MS group and the Type 2 diabetics move together with respect to the Control group for Vitamin D deficiency (p = 0.00014), and with increased triglycerides (p<0.00005), and decreased HDL (p<0.00005), while there are also significantly increased BMI (p<0.00005), CRP (p=0.04326) and systolic BP (p=0.0003) values compared to the control group. New findings from the report by Reis, JP et al, (Diabetes Care 30 (21007) 1549) on hyperparathyroidism in MS, where this does not appear to be the case in Type 2 diabetics (Taylor WH. Khakeeli Dia Met Res Rev 17(3) (2001) 175. Additional studies, relative to weight control, vitamin D deficiency and normalizing parathyroid function in MS will be necessary to clarify this important issue.