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Centrally‐located body fat is related to appetitive hormones in healthy postmenopausal women
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.878.3
Subject(s) - medicine , endocrinology , ghrelin , leptin , adiponectin , hormone , lean body mass , waist , insulin , menopause , obesity , waist–hip ratio , insulin resistance , body weight
We examined centrally‐located and/or overall adiposity in relation to appetitive hormones (adiponectin, leptin, insulin, ghrelin) in 242 healthy postmenopausal women. Overall and regional body composition was assessed by dual‐energy X‐ray absorptiometry in relation to appetitive hormones. Regression analyses revealed that 28% of the variability in adiponectin was accounted for by androidal‐to‐gynoidal fat mass ratio (18.0%), age (3.2%), and white blood cell count (1.8%); 62% of the variability in leptin was accounted for by androidal (waist+hip) fat mass (59.9%), whole body lean mass (1.8%), and age (0.5%); 32% of the variability in insulin was accounted for by sagittal diameter (8.4%), glucose (5.4%), white blood cell count (2.6%), and dietary omega‐3 fatty acids (2.0%); 26% of the variability in ghrelin was accounted for by waist circumference (12.7%), hip lean mass (2.0%), and white blood cell count (1.9%). Our results indicated that centralized fat was the primary contributor to these appetitive hormones ( P ≤0.0001) in postmenopausal women. Since central adiposity in postmenopausal women may alter appetitive hormones, minimizing further weight gain during menopause may attenuate the potential change in appetitive hormones, thereby diminishing further gain in central fat mass.