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When given in a rapidly absorbed form, a protein meal favors the splanchnic extraction and metabolism of dietary N at the expense of its peripheral uptake and anabolic use
Author(s) -
Fromentin Claire,
Deglaire Amelie,
Bos Cécile,
Gaudichon Claire,
Airinei Georges,
Moughan Paul,
Tome Daniel,
Fouillet Hélène
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.869.3
Subject(s) - postprandial , anabolism , catabolism , splanchnic , chemistry , medicine , endocrinology , metabolism , casein , meal , absorption (acoustics) , biochemistry , insulin , biology , food science , hemodynamics , physics , acoustics
Though we recently showed that, compared to casein, soluble milk protein were more extracted in the splanchnic bed but contributed less to peripheral protein accretion, the specific influence of the absorption kinetics of dietary protein, independently of their amino acid (AA) profile, on their further anabolism in individual tissues remains unknown. Clinical experiment was coupled with compartmental modeling to investigate the postprandial utilization of proteins of similar composition: intact (CA) and hydrolyzed (CH) casein. Experimental data were obtained in intestine, blood and urine for meal nitrogen (N m ) kinetics after a 15 N‐labeled CA or CH meal and analyzed using a 13‐compartment model to predict the cascade of N m absorption, transfer and regional metabolism. Compared to CA, CH had a similar whole‐body postprandial retention of N m , but a faster rate of absorption, resulting in earlier and stronger hyperaminoacidemia and hyperinsulinemia. The faster kinetics of N m absorption after CH favored both its catabolic (+25%) and anabolic (+40%) utilization in the splanchnic bed and lowered its further peripheral availability, which felt from 22% to 13% of the dietary N absorbed. The kinetics of dietary AA delivery thus constituted an independent factor of modulation of their regional metabolism in the postprandial phase, a fast supply favoring the splanchnic N m uptake over its peripheral anabolic use.