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Parenteral amino acid intakes in critically ill children
Author(s) -
Sy Jama,
Gordon William E,
Verbruggen Sascha,
Arrivillaga Ana,
Lane Craig,
Stein Fernando,
Castillo Leticia
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.869.26
Subject(s) - critically ill , parenteral nutrition , medicine , enteral administration , amino acid , methionine , pediatrics , intensive care medicine , chemistry , biochemistry
Parenteral amino acid formulas used in parenteral nutrition have a variable composition. To determine the amino acid intake of parenterally fed, critically ill children, and compare it with recommended dietary allowances (RDA) established by the Institute of Medicine (IOM), we retrospectively reviewed parenteral methionine intakes of 47 critically ill children, age 1 to 3 y, weight 8.6+2.9kg, admitted to the PICU over a 6 month period, who received TPN at full maintenance needs at least for 3 days. Eleven children received Aminosyn and 36 received Trophamine. Results are shown in Table 1. Conclusions: Critically ill, parenterally fed children receive significantly higher (P<0.001) amounts of indispensable amino acids when compared to recommended enteral dietary intakes by the IOM, or to the estimated composition of amino acids incorporated into acute phase proteins. Indispensable amino acids are potentially toxic. Hence, specific functional and nutritional parenteral amino acid requirements in critically ill children need to be determined. NIH DK‐62363, T32 HD‐007445, Ajinomoto 3‐ARP; USDA/ARS 25337387, Sophia Foundation for Scientific Research