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A Study on Relations between Biomarkers and Risk of Diabetes
Author(s) -
Liu Shumei
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.866.14
Subject(s) - prediabetes , dyslipidemia , medicine , diabetes mellitus , ferritin , endocrinology , hemoglobin , obesity , type 2 diabetes
To identify diabetes‐related biomarkers, we recruited 1074 participants with multistage, randomized cluster sampling scheme based on economic levels. Interviewer‐administered questionnaires were employed for collecting data on health, physical activity and dietary intakes. Blood samples were tested in participants available. The overall prevalence of diagnosed diabetes, based on fasting glucose and 2‐h post glucose load (OGTT), was 2.8%, including 2 % for newly diagnosed diabetes. As risk factors, obesity (esp. central adiposity), levels of hemoglobin and serum ferritin, and dyslipidemia affected diabetes at different levels when those factors were treated as monofactorial variables. Higher levels of hemoglobin, serum ferritin, total cholesterol, triglyceride and low density lipoprotein cholesterol, and lower level of high density lipoprotein cholesterol increased risk of prediabetes/diabetes. Persons with normal hemoglobin had higher risk to suffer from diabetes than those with anemia and furthermore the pattern scores of “Diabetes risk dietary pattern” were closely related to levels of hemoglobin. Although higher level of serum ferritin increased risk of diabetes, this effect appeared independent of the dietary pattern identified. In addition, the study showed that dyslipidemia was an important risk factor of prediabetes and diabetes, and the pattern deteriorated dyslipidemia.