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Differential role of lung dendritic cells and macrophages against influenza virus infection
Author(s) -
Song JooHye,
Seo SangUk,
Kweon MiNa
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.857.13
Subject(s) - cd11c , virus , immunology , virology , influenza a virus , immune system , biology , lung , microbiology and biotechnology , medicine , biochemistry , gene , phenotype
Influenza virus is a major cause of epidemic acute respiratory tract infections that have a high rate of mortality. Antigen‐presenting cells (APC), including dendritic cells (DC) or macrophages, may play a central role in eliciting innate and adaptive immune responses to influenza virus infection in the lung. We attempted to clarify the role of lung APC for protection of influenza virus infection. Balb/c and C57BL/6 mice were infected intranasally with a virulent A/PR8 influenza virus (10 5 PFU) and lung APC were analyzed 48 hr later. Interestingly, CD11c + B220 + mPDCA + Gr‐1 + cells (pDC), CD11c + B220 − CD11b + Gr‐1 − (cDC), and CD11c − F4/80 − Mac‐3 + cells (Macrophage) mainly infiltrated into the lung 48 hr following influenza virus infection. In contrast, no significant changes were detected in numbers of CD11c + F4/80 + Mac‐3 + cells (Alveolar Macrophages). Among the lung APC, cDC represents primary cells to stimulate T cell proliferation by influenza hemagglutinin. In addition, pDC generate IFN‐γ producing T helper cells while AM and M∅ generate Th17 cells. Our studies demonstrate that each APC has a differential role in CD4 T cell differentiation during influenza virus infection.