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The relationship study between the changes of the frangible lymphocyte and the degree of destroyed liver function in fulminant viral hepatitis
Author(s) -
Wang Haibin
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.856.28
Subject(s) - fulminant , fulminant hepatitis , lymphocyte , medicine , hepatitis , immunology , t lymphocyte , gastroenterology , immune system
32 cases confirmed with fulminant hepatitis and 66 cases with chronic hepatitis have been studied. 100 μl lymphocytes (1×10 6 /ml) and 100 μl tumor cells(1×10 5 /ml) mixed with 100 μl self‐serum at 37° C for 5 min to 30 min. The lymphocyte attached with tumor cell is undestroyed anything can be regarded as negative frangible lymphocyte. Less than 30 percent of lymphocyte attached with tumor cells is destroyed will be conformed as low‐grade frangible lymphocyte, between 30 percent to 60 percent regard as mid‐grade, and more than 60 percent as severe‐grade mode. The frangible lymphocyte is detected in fulminant hepatitis and other groups like that in SARS in 2003 years. 3 person's lymphocytes show severe‐grade frangible and 9 people display mid‐grade in 46 adult individuals. Contrarily There is high of 46.9 percent of cases with fulminant hepatitis show severe‐grade frangible lymphocytes, only 4 cases is negative and 75 percent is recovered in one months. The proportion of frangible lymphocytes in fulminant hepatitis is highest, and significantly higher than that in chronic hepatitis. The phenomenon of frangible lymphocytes may be an important characteristic of an innate immunology reaction of the body.