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T cell migration and memory differentiation within the mouse intestinal mucosa in response to infection
Author(s) -
Masopust David,
Vezys Vaiva,
Wherry E. John,
Ahmed Rafi
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.855.6
Subject(s) - biology , homing (biology) , intestinal mucosa , immunology , memory t cell , phenotype , cd8 , cytotoxic t cell , microbiology and biotechnology , t cell , compartment (ship) , intestinal epithelium , immune system , epithelium , in vitro , medicine , genetics , gene , ecology , oceanography , geology
Analyses in mice have revealed that the phenotype and function of pathogen‐specific memory CD4 and CD8 T cells vary considerably between gut and other anatomic locations. Understanding T cell migration and differentiation within the gut is of particular interest, given the predisposition of this tissue to infection from a variety of pathogens and the observation that the gut is an immediate and critical target of HIV. We have found that T cell migration to the small intestinal epithelium occurs only during the first few days after T cell activation, regardless of the route of infection, and provide evidence that memory T cells within this compartment do not recirculate. We will present data demonstrating that the unique qualities of memory CD8 T cells within the intestinal mucosa are partly regulated in situ by tissue‐specific factors. We are currently dissecting the developmental cues that regulate expression of the gut homing machinery by activated T cells. These studies may provide new strategies for establishing cellular immunity preferentially within the intestinal mucosa.