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The synergistic effect of Hemokinin 1 in the activation of mature B lymphocytes
Author(s) -
wang wei,
Zhang Yu
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.847.7
Subject(s) - cd80 , b cell , chemistry , lymphopoiesis , microbiology and biotechnology , substance p , cd40 , t cell , endocrinology , immunology , biology , antibody , immune system , neuropeptide , stem cell , biochemistry , receptor , in vitro , cytotoxic t cell , haematopoiesis
Hemokinin 1 (HK‐1) is a substance P‐like peptide of the tachykinin family. Previous studies have demonstrated that, by promoting the proliferation and survival of lymphoid precursors, HK‐1 is involved in lymphopoiesis. The current study was undertaken to investigate the potential role of HK‐1 in the activation of mature B lymphocytes. HK‐1 alone had no significant effect on mature B cells. On the other hand, it was able to synergize with many of those classical B cell stimulators in their induction of B cell activation. When B cells were stimulated with suboptimal concentrations of LPS, anti‐IgM or CD40, addition of HK‐1 significantly increased cell proliferation, expression of CD80/86, and the frequency of Ig‐secreting cells as well as the absolute amount of secreted Ig. Intriguingly, even more potent synergistic effects were observed with memory B cells. Thus, we suggest that HK‐1 may be a co‐stimulatory factor in the activation of naïve B cells and in the maintenance of B cell memory.