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Genesis of tear duct‐associated lymphoid tissue is independent of Id2, RORγt but requires Cbfβ2 transcriptional regulator
Author(s) -
Nagatake Takahiro,
Fukuyama Satoshi,
Tachibana Masashi,
Taniuchi Ichiro,
Kim DongYoung,
Takamura Kaoru,
Sato Shintaro,
Kunisawa Jun,
Kiyono Hiroshi
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.845.1
Subject(s) - lymphatic system , biology , rar related orphan receptor gamma , gene isoform , transcriptional regulation , runx1 , lymph , immunology , transcription factor , pathology , microbiology and biotechnology , medicine , genetics , gene
We have previously reported the presence of tear duct‐associated lymphoid tissue (TALT) in the murine lacrimal sac and demonstrated that the organogenesis program of TALT was distinctively different from other secondary lymphoid organs including Peyer's patch (PP) and nasopharynx‐associated lymphoid tissue (NALT). Indeed, developmental program of TALT did not require a common tissue genesis program family of Id2, RORγt and LTα1 β2/LTβR‐mediated signals. However, essential molecule for the TALT genesis remained to be identified. Transcriptional factor complexes composed of Cbfβ2 and Runx1 were recently shown to play an important role for development of PP and peripheral lymph nodes (pLNs) by regulating early differentiation of lymphoid tissue inducer (LTi) lineage cells in fetal liver. Here we demonstrate that mice deficient for Cbfβ2 lack both TALT and PP, while mice deficient for P1‐Runx1 isoform exhibited normal TALT development with decreased numbers of PP. These findings suggest conserved functions of Cbfβ2 in the common developmental program of secondary lymphoid tissues, and an involvement of other Runx protein(s) as a partner of Cbfβ2 in initiating TALT development.